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5-(4-Bromophenyl)-4,6-dichloropyrimidine
- CAS: 146533-41-7
- Purity: 99%
- Top quality factory supply 146533-41-7 5-(4-Bromophenyl)-4,6-dichloropyrimidine at low price
Quality products?make an important contribution to long-term revenue and profitability. Top quality factory supply 146533-41-7 5-(4-Bromophenyl)-4,6-dichloropyrimidine at low price
1.What is the 5-(4-Bromophenyl)-4,6-dichloropyrimidine ?
5-(4-Bromophenyl)-4,6-dichloropyrimidine is a reactant used in the synthesis of Macitentan, an orally active dual endothelin receptor antagonist.
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1878-68-8
2-(4-bromophenyl)-acetic acid
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146533-41-7
5-(4-bromophenyl)-4,6-dichloropyrimidine
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
4
steps
1.1: 94 percent / conc. HCl / Heating
2.1: LHMDS / tetrahydrofuran; hexane / -78 °C
2.2: 66 percent / tetrahydrofuran; hexane / -78 - 20 °C
3.1: 51 percent / NaOEt / ethanol / 60 °C
4.1: 67 percent / POCl3
/ 90 °C
With
hydrogenchloride; sodium ethanolate; lithium hexamethyldisilazane; trichlorophosphate;
In
tetrahydrofuran; ethanol; hexane;
|
|
|
Multi-step reaction
with
4
steps
1.1: thionyl chloride / 0 - 20 °C
2.1: sodium hydride / tetrahydrofuran / 1.83 h / 40 °C
2.2: 22 h / 20 - 31 °C
2.3: -10 °C / pH 6 - 7
3.1: sodium / methanol / 18 h / 0 - 20 °C
3.2: 4 h / 20 °C
3.3: 0.17 h
4.1: trichlorophosphate; N
,N
-dimethyl-aniline / 2 h / 130 °C
4.2: 0.33 h / Cooling with ice
With
thionyl chloride; sodium; sodium hydride; N,N-dimethyl-aniline; trichlorophosphate;
In
tetrahydrofuran; methanol;
|
|
|
Multi-step reaction
with
4
steps
1.1: thionyl chloride / 3 h / 0 - 20 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / 5 h / 40 - 45 °C
2.2: 24 h / 20 - 32 °C
3.1: sodium / methanol / 18 h / 0 - 20 °C
3.2: 4 h / 20 °C
4.1: trichlorophosphate / N
,N
-dimethyl-aniline / 2 h / 130 °C
With
thionyl chloride; sodium; sodium hydride; trichlorophosphate;
In
tetrahydrofuran; methanol; N,N-dimethyl-aniline; mineral oil;
|
|
|
Multi-step reaction
with
4
steps
1.1: thionyl chloride / 0.5 h / 0 - 30 °C / Inert atmosphere
2.1: sodium amide / tetrahydrofuran / 1 h / 25 - 40 °C
3.1: sodium methylate; methanol / 1.25 h / 0 - 5 °C / Inert atmosphere
3.2: 6 h / 0 - 30 °C
3.3: 1.5 h / 25 - 30 °C
4.1: triethylamine; trichlorophosphate / acetonitrile / 5 h / 25 - 85 °C / Inert atmosphere
With
methanol; thionyl chloride; sodium methylate; sodium amide; triethylamine; trichlorophosphate;
In
tetrahydrofuran; acetonitrile;
|
|
|
Multi-step reaction
with
4
steps
1.1: sulfuric acid / 70 °C
2.1: sodium methylate / tetrahydrofuran / 1 h / 0 - 5 °C
2.2: 0 - 30 °C
3.1: sodium methylate / methanol / 70 °C
4.1: trichlorophosphate / 90 °C
With
sulfuric acid; sodium methylate; trichlorophosphate;
In
tetrahydrofuran; methanol;
|
|
|
Multi-step reaction
with
4
steps
1: solid acid catalyst / 5.5 h / Reflux
2: sodium methylate / methanol / 4 h / 70 °C / Inert atmosphere
3: 16 h / 25 °C
4: trichlorophosphate / toluene; N
,N
-dimethyl-aniline; water / 5 h / 30 - 100 °C
With
sodium methylate; trichlorophosphate;
In
methanol; water; N,N-dimethyl-aniline; toluene;
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146533-40-6
5-(p-bromophenyl)-4,6(1H,5H)-pyrimidinedione
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146533-41-7
5-(4-bromophenyl)-4,6-dichloropyrimidine
| Conditions | Yield |
|---|---|
|
With
trichlorophosphate;
|
2.What is the CAS number for 5-(4-Bromophenyl)-4,6-dichloropyrimidine ?
The CAS number of 5-(4-Bromophenyl)-4,6-dichloropyrimidine is 146533-41-7.
More information of 5-(4-Bromophenyl)-4,6-dichloropyrimidine 146533-41-7 are:
|
CAS?Number |
146533-41-7 |
|
Density |
1.677±0.06 g/cm3(Predicted) |
|
Melting Point |
98.0 to 102.0 °C |
|
Boiling Point |
368.7±42.0 °C(Predicted) |
|
HS CODE |
2933599590 |
|
PSA |
25.78000 |
|
LogP |
4.21290 |
|
Pka |
-4.92±0.26(Predicted) |
3.What are another words for 5-(4-Bromophenyl)-4,6-dichloropyrimidine ?
Synonyms?for?5-(4-Bromophenyl)-4,6-dichloropyrimidine 146533-41-7:QC-9668;
4.What is the molecular formula of 5-(4-Bromophenyl)-4,6-dichloropyrimidine?
The chemical formula of ?5-(4-Bromophenyl)-4,6-dichloropyrimidine is?C10H5BrCl2N2 which containing 10 Carbon atoms,5 Hydrogen atoms,1 Bromine atoms,2 Chlorine atoms and 2 Nitrogen atoms,and the molecular weight of??5-(4-Bromophenyl)-4,6-dichloropyrimidine?is 303.973.
5.What is 5-(4-Bromophenyl)-4,6-dichloropyrimidine (146533-41-7) used for?
5 - (4-Bromophenyl)-4, 6- dichloropyrimidine is a key intermediate and has a wide range of applications in the pharmaceutical and chemical fields.
Relevant articles related to 5-(4-Bromophenyl)-4,6-dichloropyrimidine:
|
Article |
Source |
|
Preparation method of 5-(4-bromophenyl)-4,6-dichloropyrimidine |
- , (2019/01/08) |
|
AN IMPROVED PROCESS FOR THE PREPARATION OF MACITENTAN |
- , (2017/09/07) |
6.Buy 5-(4-Bromophenyl)-4,6-dichloropyrimidine with the best price .
Suzhou Howsine Biological Technology Co.,Ltd is a quality supplier of 5-(4-Bromophenyl)-4,6-dichloropyrimidine. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on 5-(4-Bromophenyl)-4,6-dichloropyrimidine 146533-41-7.
